Journal of Nanomaterials
 Journal metrics
Acceptance rate49%
Submission to final decision69 days
Acceptance to publication29 days
CiteScore3.800
Journal Citation Indicator0.310
Impact Factor2.986

Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

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 Journal profile

Journal of Nanomaterials publishes research on nanoscale and nanostructured materials with an emphasis on synthesis, processing, characterization, and the applications of nanomaterials.

 Editor spotlight

Chief Editor Stefano Bellucci is Professor of Theoretical Physics at the National Institute for Nuclear Physics in Frascati, Italy. His research interests include nanoscience and nanotechnology, nanocarbon-based composites, and the biomedical applications of nanomaterials.

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We currently have a number of Special Issues open for submission. Special Issues highlight emerging areas of research within a field, or provide a venue for a deeper investigation into an existing research area.

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Research Article

Nanoconjugation between Fungal Nanochitosan and Biosynthesized Selenium Nanoparticles with Hibiscus sabdariffa Extract for Effectual Control of Multidrug-Resistant Bacteria

Multidrug-resistant (MDR) pathogenic bacteria are hazardous and ongoing threats worldwide, which urges searching for novel bioeffectual alternatives for combating MDR attacks. Herein, it was targeted to extract chitosan (Cht) from fungal culture (Mucor circinelloides) and transform it to nanochitosan (NCht), to biosynthesize selenium nanoparticles (SeNPs) directly using Hibiscus sabdariffa extract (HbE), and to conjugate these bioactive agents and assess their biocidal actions against MDR bacterial pathogens (Klebsiella pneumoniae, Salmonella typhimurium, and Staphylococcus aureus). The fungal Cht had 86.71% deacetylation and transformed effectually to NCht with a 67.6 nm average particle diameter. The SeNPs were innovatively and simply biosynthesized by direct interaction with HbE, which were validated visually, calorimetrically, and biochemically; the HbE/SeNPs had a 12.1 nm mean size. The conjugation between NCht and HbE/SeNPs was proven via structural and biochemical analysis. The entire fabricated NPs/nanocomposites exhibited elevated bactericidal actions toward all MDR pathogens; NCht/HbE/SeNPs were the most powerful with the widest growth inhibition zones and minimal bactericidal concentrations. The most sensitive bacteria were K. pneumoniae, whereas S. aureus displayed the utmost resistance. The ultrastructure of treated K. pneumoniae with NCht/HbE/SeNPs evidenced the attachment of nanocomposite particles to bacterial membranes and the full bacterial lysis/death within 8 h of exposure. The compositing of NCht with HbE-biosynthesized SeNPs provided powerful ideal bactericidal conjugates against MDR pathogens with warranted biosafety, eco-friendliness, and effectuality.

Research Article

Mechanical Behavior of Helical Spring Made of Composite with and without Material Property Grading under Stable Load

Springs are one of the most popular means of mechanically storing and issuing energy, and they can be found in a wide variety of machines and products. Most springs are made of metal, and nowadays, there are many new alloys to choose from, but nonmetallic materials, such as the reinforced plastics and ceramics, have been appearing worldwide. The research problem is the performance for circular cross-sectional springs with the same geometry and manufactured with three different materials: steel, composite, and functionally graded material (FGM) under stable loading using finite element analysis. This paper intends to guide mechanical designers in considering different material options for a spring design as well as to provide a methodology through finite element analysis for selecting the most favorable material option for the application required. The findings of this research show that some feature performances of compression springs made of carbon steel are improved by using FGM and composite materials. Enhanced capabilities include higher load to failure: 1.48 times in an FGM spring and 1.1 times in a composite spring, as well as increased energy storage: 1.53 times in an FGM spring and 6.84 times in a composite spring and less weight representing only 61% in an FGM spring and 24% in a composite spring.

Research Article

Analytical Approximate Solution of the Fractional Order Biological Population Model by Using Natural Transform

In the present work, the natural transform iterative method (NTIM) is implemented to solve the biological population model (BPM) of fractional order. The method is tested for three nonlinear examples. The NTIM is a combination of a new iterative method and natural transform. We see that the solution pattern converges to the exact solution in a few iterations. The method handles an extensive range of differential equations of both fractional and integer order. The fractional order derivative is considered in Caputo’s sense. For mathematical computation, Mathematica 10 is used.

Research Article

Therapeutic Effect of Bicyclol Coupled with Aspirin Nanopreparation on Liver Function Damage Caused by Epstein-Barr Virus Infection in Children

The aim of study effective treatment is to reach the appropriate part of the body and then maintain the required drug concentration at sufficient intervals in order to achieve the clinical therapeutic effect. Problem of the Study. Biological barrier hinders the flow of most drugs from the blood to the focus. Methods of the Study. A novel nanopreparation for inhibition of Epstein-Barr virus (EBV) was developed based on poly (lactic-co-glycolic acid) (PLGA) nanodrug carriers loaded with bicyclic alcohol (BA) and aspirin (Asp) (PLGA-BA/Asp). Among them, the addition of PLGA can effectively improve the low solubility of BA and poor oral availability. Results have revealed that PLGA-BA/Asp is a multifunctional therapeutic drug that integrates antivirus, treatment of liver damage, and regulation of the immune system. This discovery provides a new treatment method for the treatment of liver injury in children with EBV infection.

Research Article

Construction of MPEG-PCL Nanomicelle Ocular Drug Delivery Vector and Its Application in the Treatment of Hypertensive Fundus Disease

With the continuous development of society and the continuous development of technology, people’s living standards have gradually improved, and the development of new things has gradually entered a new agenda. Alcoholism has gradually taken over most people’s lives. Excessive drinking can lead to excessive alcohol content in the body, which is harmful to the liver. The stomach and other organs are affected, and the formation of high blood pressure is directly related to excessive drinking. And hypertensive patients are prone to have some adverse reactions and cause other more serious diseases. Hypertensive ocular fundus disease is one of its complications. Hypertensive ophthalmopathy is caused by abnormal changes in the retina, which can be very harmful. Patients with low rates and blindness can cause vision loss. Such diseases must be treated in time to allow patients to get rid of the troubles of the disease as soon as possible and restore their quality of life. In the treatment of hypertensive fundus disease, low-intensity laser radiation combined with nanomicelle ocular drug delivery carrier treatment has achieved a relatively ideal treatment effect. This article adopts the comparative treatment method and selects 120 patients with hypertensive ocular fundus disease admitted to X Hospital from 2018 to 2020 and evenly distributes them into the experimental group and the control group for comparative treatment experiments. Conclusions are obtained based on the analysis of treatment data. Related factors analyzed include age, gender, whether retinal laser photocoagulation has been performed before, and whether anti-VEGF treatment has been performed before surgery. The experimental results proved that there was no difference in the overall quality of life between the two groups before the treatment and at the end of the first course of treatment (), and the overall quality of life of the experimental group was higher than that of the control group until the end of the second course of treatment (). Hypertensive fundus disease is very harmful. If it is not treated in time, it will cause blindness in patients. In the treatment of hypertensive fundus disease, the use of low-intensity laser irradiation combined with MPEG-PCL nanomicelle therapy is beneficial to the recovery of vision and blood flow. The change index can guarantee the safety of treatment at the same time, which is worthy of clinical promotion.

Research Article

Investigation on the Performance of Domestic Refrigerator with Zirconium Oxide-R134a Nanorefrigerant

This study investigates the performance of nanorefrigerants (R134a-ZrO2) in a domestic refrigerator at a concentration of 0.2 g/l without changing the components. Nanoparticles of ZrO2 of 0.2 g/L concentration with particle size 1-10 nm and 140 g of R134a have been charged, and investigations were carried out. Energy consumption and pull-down tests were conducted to investigate the performance of the refrigerator. The performance parameters like refrigeration capacity, compressor power, discharge temperature, coefficient of performance, and energy consumption were investigated for the nanorefrigerant (R134a-ZrO2), and the results were compared with base refrigerant R134a. The pull downtime, energy consumption, and discharge temperature are reduced with increased COP and compressor power when the system is operated with R134a-ZrO2 nanorefrigerant. Also, the thermophysical properties of the nanorefrigerant (R134a-ZrO2) are calculated and analyzed for the various volume fraction of nanoparticles.

Journal of Nanomaterials
 Journal metrics
Acceptance rate49%
Submission to final decision69 days
Acceptance to publication29 days
CiteScore3.800
Journal Citation Indicator0.310
Impact Factor2.986
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.